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Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.

Abstract:

The first proteomic characterization of the HepaRG cell line, the only cell line that is susceptible to hepatitis B virus (HBV) infection and supports a complete virus life cycle, is reported. Differential analysis of naive and HBV-infected HepaRG cells by two-dimensional gel electrophoresis revealed 19 differentially regulated features, 7 increasing and 12 decreasing with HBV infection. The proteins identified in these features were involved in various cellular pathways including apoptosis, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/pr800562j

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Oxford Glycobiology Endowment More from this funder
Agence Nationale de Recherches More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of proteome research Journal website
Volume:
8
Issue:
1
Pages:
118-122
Publication date:
2009-01-01
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
URN:
uuid:70c5bd49-8413-4201-a0b7-65051cb570b4
Source identifiers:
100145
Local pid:
pubs:100145

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