Serum fasting cortisol in relation to bone, and the role of genetic variations in the glucocorticoid receptor.
OBJECTIVE: To examine the relationship between endogenous cortisol and bone, and the role of genetic variations in the glucocorticoid receptor (GR). DESIGN AND PATIENTS: The Longitudinal Ageing Study Amsterdam (LASA), a population-based cohort study in older men and women. MEASUREMENTS: Serum fasting cortisol was assessed by competitive immunoassay (n = 1214); bone mineral density (BMD) by dual X-ray absorptiometry (DXA) (n = 502); broadband ultrasound attenuation (BUA) by ultrasound (n = 120...Expand abstract
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