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Severe scene learning impairment, but intact recognition memory, after cholinergic depletion of inferotemporal cortex followed by fornix transection

Abstract:

To examine the generality of cholinergic involvement in visual memory in primates, we trained macaque monkeys either on an object-in-place scene learning task or in delayed nonmatching-to-sample (DNMS). Each monkey received either selective cholinergic depletion of inferotemporal cortex (including the entorhinal cortex and perirhinal cortex) with injections of the immunotoxin ME20.4-saporin or saline injections as a control and was postoperatively retested. Cholinergic depletion of inferot...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cercor/bhp097

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Institution:
University of Oxford
Department:
Medical Sciences Division - Experimental Psychology
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Institution:
University of Oxford
Department:
Medical Sciences Division - Experimental Psychology
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Experimental Psychology
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Experimental Psychology
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Funding agency for:
Philip G. F. Browning
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Funding agency for:
David Gaffan
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Funding agency for:
Paula L. Croxson
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Funding agency for:
Mark G. Baxter
Journal:
Cerebral Cortex Journal website
Volume:
20
Issue:
2
Pages:
282-293
Publication date:
2010-02-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:70a71d88-da1a-41de-9396-c1e2a4345345
Local pid:
ora:7792

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