Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors.

Journal article

The commitment of multipotent cells to particular developmental pathways requires specific changes in their transcription factor complement to generate the patterns of gene expression characteristic of specialized cell types. We have studied the role of the GATA cofactor Friend of GATA (FOG) in the differentiation of avian multipotent hematopoietic progenitors. We found that multipotent cells express high levels of FOG mRNA, which were rapidly down-regulated upon their C/EBPbeta-mediated comm...

Expand abstract

Authors: Querfurth, E; Schuster, M; Kulessa, H; Crispino, J; Döderlein, G

• Journal: Genes and development
• Volume: 14
• Issue: 19
• Pages: 2515-2525
• Publication date: 2000-10-01
• DOI: 10.1101/gad.177200
• EISSN: 1549-5477
• ISSN: 0890-9369
• Language: English
• Keywords: CCAAT-Enhancer-Binding Protein-beta; Myeloid Cells; Gene Expression Regulation; Phenotype; Carrier Proteins; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; Cell Lineage; Hematopoietic Stem Cells; Nuclear Proteins; Avian Proteins; Chick Embryo; Membrane Glycoproteins; Promoter Regions, Genetic; Transcription Factors; Down-Regulation; Eosinophils; Models, Genetic; Animals; Cell Differentiation