- Abstract:
- We report the highly efficient and scalable Rh(III)-catalyzed C–H coupling of arenes with diazo-methylene-diphosphonates to give structurally diverse aromatic bisphosphonates in good to excellent yields. These bisphosphonates are one of the very few classes of inhibitors acting against the mechanistically distinct metallo-β-lactamases and serine-β-lactamases and thus represent good starting points for the development of broad spectrum β-lactamase inhibitors.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 11.4MB)
-
- Publisher copy:
- 10.1039/C8QO00009C
-
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- Grant:
- 81773577; 81573286; 81502989
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Organic Chemistry Frontiers Journal website
- Volume:
- 5
- Issue:
- 8
- Pages:
- 1288-1292
- Publication date:
- 2018-02-01
- Acceptance date:
- 2018-01-13
- DOI:
- EISSN:
-
2052-4129
- ISSN:
-
2052-4110
- Pubs id:
-
pubs:823133
- URN:
-
uri:70a19b91-9f3b-4826-9004-61fc15e53409
- UUID:
-
uuid:70a19b91-9f3b-4826-9004-61fc15e53409
- Local pid:
- pubs:823133
- Copyright holder:
- Zhang et al.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 the Authors. This is the accepted manuscript version of the article. The final version is available online from Royal Society of Chemistry at: https://doi.org/10.1039/C8QO00009C
Journal article
Rh(III)-catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases
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+ National Natural Science Foundation of China
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Wellcome Trust
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Medical Research Council
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