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A TFEB nuclear export signal integrates amino acid supply and glucose availability

Abstract:

How cells coordinate the response to fluctuating carbon and nitrogen availability required to maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation and nuclear translocation of Transcription Factor EB (TFEB), a key transcriptional regulator of lysosome biogenesis and autophagy that is deregulated in cancer and neurodegeneration. Beyond its cytoplasmic sequestration, how TFEB phosphorylation regulates its nuclear-cytoplasmic sh...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-04849-7

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
NDM; Structural Genomics Consortium
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 2685
Publication date:
2018-07-11
Acceptance date:
2018-05-22
DOI:
EISSN:
2041-1723
Pubs id:
pubs:865261
URN:
uri:70992714-2942-42d1-8b21-d39fb194b35f
UUID:
uuid:70992714-2942-42d1-8b21-d39fb194b35f
Local pid:
pubs:865261

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