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The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef.

Abstract:

The thiol-ene coupling reaction is emerging as an important conjugation reaction that is suitable for use in a biological setting. Here, we explore the utility of this reaction for the synthesis of glutathione-S-conjugates (GSX) and present a general, operationally simple, protocol with a wide substrate scope. The GSX afforded are an important class of compounds and provide invaluable molecular tools to study glutathione-binding proteins. In this study we apply the diverse library of GSX synt...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/c5qo00436e

Authors


Rasmussen, T More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Organic Chemistry Frontiers: an International Journal of Organic Chemistry Journal website
Volume:
3
Issue:
4
Pages:
439-446
Publication date:
2016-02-15
Acceptance date:
2015-02-15
DOI:
EISSN:
2052-4129
ISSN:
2052-4110
URN:
uuid:708ad994-20c4-41ae-9da1-379f823868ca
Source identifiers:
618124
Local pid:
pubs:618124
Language:
English
Keywords:

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