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Targeted alpha therapy with 212Pb or 225Ac: Change in RBE from daughter migration

Abstract:

Targeted α-therapy (TAT) could be delivered early to patients who are at a high-risk for developing brain metastases, targeting the areas of the vasculature where tumor cells are penetrating into the brain. We have utilized a Monte Carlo model representing brain vasculature to calculate physical dose and DNA damage from the α-emitters 225Ac and 212Pb. The micron-scale dose distributions from all radioactive decay products were modeled in Geant4, including the eV-scale interactions using the G...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ejmp.2018.05.020

Authors


Ackerman, NL More by this author
De La Fuente Rosales, L More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
ORCID:
0000-0003-4672-5683
Bernal, MA More by this author
Brazilian National Council for Scientific and Technological Development More from this funder
Gravatt Women in Science Innovation Fund More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Physica Medica Journal website
Volume:
51
Pages:
91-98
Publication date:
2018-05-25
Acceptance date:
2018-05-18
DOI:
EISSN:
1724-191X
ISSN:
1120-1797
Pubs id:
pubs:854456
URN:
uri:7082ef8e-64a8-4672-b28b-15ecee489657
UUID:
uuid:7082ef8e-64a8-4672-b28b-15ecee489657
Local pid:
pubs:854456

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