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The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.

Abstract:

The transcription factor Runx1 plays a pivotal role in hematopoietic stem cell (HSC) emergence, and studies into its transcriptional regulation should give insight into the critical steps of HSC specification. Recently, we identified the Runx1 +23 enhancer that targets reporter gene expression to the first emerging HSCs of the mouse embryo when linked to the heterologous hsp68 promoter. Endogenous Runx1 is transcribed from 2 alternative promoters, P1 and P2. Here, we examined the in vivo cis-...

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Publication status:
Published

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Journal:
Blood
Volume:
113
Issue:
21
Pages:
5121-5124
Publication date:
2009-05-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:707b2f8c-ddf1-4afc-8fc9-3a5450ccf6a5
Source identifiers:
263062
Local pid:
pubs:263062

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