Journal article
Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
- Abstract:
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Background
Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts.
Methods
We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline.
Results
Some associations were observed at higher concentrations of p, p’-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk.
Conclusions
Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 507.9KB, Terms of use)
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- Publisher copy:
- 10.1093/ije/dyab115
Authors
- Publisher:
- Oxford University Press
- Journal:
- International Journal of Epidemiology More from this journal
- Volume:
- 51
- Issue:
- 2
- Pages:
- 479-490
- Publication date:
- 2022-07-14
- Acceptance date:
- 2021-05-15
- DOI:
- EISSN:
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1464-3685
- ISSN:
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0300-5771
- Pmid:
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34259837
- Language:
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English
- Keywords:
- Pubs id:
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1266992
- Local pid:
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pubs:1266992
- Deposit date:
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2022-08-15
Terms of use
- Copyright holder:
- Porta et al.
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected]
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