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A pooled shRNA screen identifies Rbm15, Spen, and Wtap as factors required for Xist RNA-mediated silencing

Abstract:

X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-linked gene expression in XX females relative to XY males. Silencing of a single X chromosome in female cells is mediated by the non-coding RNA Xist. Although progress has been made toward identifying factors that function in the maintenance of X inactivation, the primary silencing factors are largely undefined. We developed an shRNA screening strategy to produce a ranked list of candidate primary silenci...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2015.06.053

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry, Developmental Epigenetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry, Developmental Epigenetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry, Developmental Epigenetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry, Developmental Epigenetics
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More from this funder
Funding agency for:
Brockdorff, N
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
12
Issue:
4
Pages:
562–572
Publication date:
2015-07-28
DOI:
EISSN:
2211-1247
URN:
uuid:70634369-fbd2-43a3-9005-38f945ffd895
Source identifiers:
533708
Local pid:
pubs:533708
Language:
English

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