Journal article
A pooled shRNA screen identifies Rbm15, Spen, and Wtap as factors required for Xist RNA-mediated silencing
- Abstract:
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X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-linked gene expression in XX females relative to XY males. Silencing of a single X chromosome in female cells is mediated by the non-coding RNA Xist. Although progress has been made toward identifying factors that function in the maintenance of X inactivation, the primary silencing factors are largely undefined. We developed an shRNA screening strategy to produce a ranked list of candidate primary silenci...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 4.2MB)
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- Publisher copy:
- 10.1016/j.celrep.2015.06.053
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 12
- Issue:
- 4
- Pages:
- 562–572
- Publication date:
- 2015-07-28
- DOI:
- EISSN:
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2211-1247
- Source identifiers:
-
533708
Item Description
- Language:
- English
- Pubs id:
-
pubs:533708
- UUID:
-
uuid:70634369-fbd2-43a3-9005-38f945ffd895
- Local pid:
- pubs:533708
- Deposit date:
- 2015-07-31
Terms of use
- Copyright holder:
- Moindrot et al
- Copyright date:
- 2015
- Notes:
- This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Open Access funded by Wellcome Trust.
- Licence:
- CC Attribution (CC BY)
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