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USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.

Abstract:

In response to genotoxic stress, DNA damage checkpoints maintain the integrity of the genome by delaying cell cycle progression to allow for DNA repair. Here we show that the degradation of the basic helix-loop-helix (bHLH) transcription factor DEC1, a critical regulator of cell fate and circadian rhythms, controls the DNA damage response. During unperturbed cell cycles, DEC1 is a highly unstable protein that is targeted for proteasome-dependent degradation by the SCF(βTrCP) ubiquitin ligase ...

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Publication status:
Published

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Publisher copy:
10.1128/mcb.00530-14

Authors


D'Annibale, S More by this author
Magliozzi, R More by this author
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Publisher:
American Society for Microbiology
Journal:
Molecular and cellular biology
Volume:
34
Issue:
22
Pages:
4177-4185
Publication date:
2014-11-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:7062319d-0aef-4a7b-a457-e5a70111c336
Source identifiers:
484159
Local pid:
pubs:484159
Language:
English

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