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Journal article

Beta-catenin mutations in cell lines established from human colorectal cancers.

Abstract:

beta-catenin has functions as both an adhesion and a signaling molecule. Disruption of these functions through mutations of the beta-catenin gene (CTNNB1) may be important in the development of colorectal tumors. We examined the entire coding sequence of beta-catenin by reverse transcriptase-PCR (RT-PCR) and direct sequencing of 23 human colorectal cancer cell lines from 21 patients. In two cell lines, there was apparent instability of the beta-catenin mRNA. Five different mutations (26%) wer...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.94.19.10330

Authors


Tomlinson, IP More by this author
Pignatelli, M More by this author
Bodmer, WF More by this author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
94
Issue:
19
Pages:
10330-10334
Publication date:
1997-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:705ccafa-4947-4114-821f-7dc49a4fd909
Source identifiers:
72327
Local pid:
pubs:72327

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