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Journal article

In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound.

Abstract:

1. The MIN6 cell line derived from in vivo immortalized insulin-secreting pancreatic beta cells was used to study the insulin-releasing capacity and the cellular mode of action of S-22068, a newly synthesized imidazoline compound known for its antidiabetic effect in vivo. 2. S-22068, was able to release insulin from MIN6 cells in a dose-dependent manner with a half-maximal stimulation at 100 micronM. Its efficacy (8 fold over the basal value), which did not differ whatever the glucose concent...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjp.0702883

Authors


Le Brigand, L More by this author
Virsolvy, A More by this author
Manechez, D More by this author
Godfroid, JJ More by this author
Guardiola-Lemaître, B More by this author
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Journal:
British journal of pharmacology
Volume:
128
Issue:
5
Pages:
1021-1026
Publication date:
1999-11-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:7057de50-073a-47e2-9dd5-7eb284dfd38a
Source identifiers:
114459
Local pid:
pubs:114459

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