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Alpha-glucosidase inhibitors prevent the assembly and induce a reduction of HCV infectivity

Abstract:

HCV morphogenesis is a key step of the viral cycle and represents an original target for the development of new antivirals that could complement more conventional antiviral strategies based on inhibition of viral enzymes. As proof of concept, the inhibition of morphogenesis was demonstrated using the BVDV, a pestivirus related to HCV, as a surrogate model. Using this model, it was shown that alpha-glucosidase inhibitors, i.e. deoxynojirimyci...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Journal of Clinical Virology Journal website
Volume:
36
Pages:
S110-S110
Publication date:
2006-08-26
DOI:
ISSN:
1386-6532
Source identifiers:
100878
Pubs id:
pubs:100878
UUID:
uuid:705622ae-b0b5-468c-8948-db6472580e37
Local pid:
pubs:100878
Deposit date:
2012-12-19

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