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DNA Instability in premature aging

Abstract:

DNA damage accumulates with increased chronological age and may contribute to both cell senescence and cancer. However, the importance and role(s) of DNA damage in promoting ageing is difficult to analyze experimentally at the molecular level since ageing results from a complex interplay of genetic and environmental factors. Premature human ageing syndromes offer a route to determining the molecular basis of at least some of the changes in DNA associated with normal ageing, as they are caused...

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Publisher:
Nova Science Publishers, Inc.
Pages:
1-34
Host title:
DNA Damage Repair, Repair Mechanisms and Aging
Publication date:
2012-01-01
URN:
uuid:705386f8-5c27-4cdc-9166-557ffecdff4f
Source identifiers:
184629
Local pid:
pubs:184629
ISBN:
9781616689148

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