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Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum.

Abstract:

The immunodominant CD4 T cell epitope region, Th2R, of the circumsporozoite protein of Plasmodium falciparum is highly polymorphic. Such variation might be utilized by the parasite to escape from or interfere with CD4 T cell effector functions. Here, we show that costimulation with naturally occurring altered peptide ligands (APL) can induce a rapid change from IFNgamma production to the immunosuppressive mediator interleukin 10 (IL-10). This mechanism may contribute to the low levels of T ce...

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Publication status:
Published

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Journal:
Immunity
Volume:
10
Issue:
6
Pages:
651-660
Publication date:
1999-06-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:70522c13-2daf-4a20-b720-4d746fd08f82
Source identifiers:
31521
Local pid:
pubs:31521

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