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A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells.

Abstract:

The evolution of the cell-cycle is known to be influenced by environmental conditions, including lack of extracellular oxygen (hypoxia). Notably, hypoxia appears to have different effects on normal and cancer cells. Whereas both experience hypoxia-induced arrest of the G1 phase of the cell-cycle (i.e. delay in the transition through the restriction point), experimental evidence suggests that only cancer cells undergo hypoxia-induced quiescence (i.e. the transition of the cell to a latent stat...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2004.04.016

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of theoretical biology
Volume:
229
Issue:
3
Pages:
395-411
Publication date:
2004-08-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:703d24ac-0c11-4f97-a469-c9b1625c4d1b
Source identifiers:
25527
Local pid:
pubs:25527

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