Journal article
A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells.
- Abstract:
-
The evolution of the cell-cycle is known to be influenced by environmental conditions, including lack of extracellular oxygen (hypoxia). Notably, hypoxia appears to have different effects on normal and cancer cells. Whereas both experience hypoxia-induced arrest of the G1 phase of the cell-cycle (i.e. delay in the transition through the restriction point), experimental evidence suggests that only cancer cells undergo hypoxia-induced quiescence (i.e. the transition of the cell to a latent stat...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of theoretical biology
- Volume:
- 229
- Issue:
- 3
- Pages:
- 395-411
- Publication date:
- 2004-08-01
- DOI:
- EISSN:
-
1095-8541
- ISSN:
-
0022-5193
- Source identifiers:
-
25527
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:25527
- UUID:
-
uuid:703d24ac-0c11-4f97-a469-c9b1625c4d1b
- Local pid:
- pubs:25527
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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