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Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and improved outcome.

Abstract:

Neuropathology in multiple sclerosis is closely linked to presence of macrophages in the CNS. Both M1 (inflammatory) and M2 (alternatively activated, noninflammatory) macrophages are found in the inflamed CNS and thought to differentiate from infiltrating monocytes. It is unclear whether the balance of M1 and M2 macrophages can be altered and whether this affects disease outcome. We show in this article that Ly6C(hi) inflammatory monocytes are the early and dominant infiltrating cells in the ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1103608

Authors


Sanderson, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
189
Issue:
2
Pages:
551-557
Publication date:
2012-07-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:7037521f-4533-4ac4-ae66-9dbf716381fd
Source identifiers:
339815
Local pid:
pubs:339815

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