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Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node.

Abstract:

Ab-secreting cell (ASC) expansion and survival are important processes in optimizing vaccines and controlling autoimmunity. The microenvironment of the medullary cords is positioned to control these key processes. Previously, we imaged and characterized ASC differentiation and migration by intravital microscopy in the lymph node (LN) by transferring and activating B cells expressing yellow fluorescent protein only in the ASC compartment. In this study, we observed that yellow fluorescent prot...

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Publisher copy:
10.4049/jimmunol.1300977

Authors


Fooksman, DR More by this author
Nussenzweig, MC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
192
Issue:
3
Pages:
1004-1012
Publication date:
2014-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:701ad3f7-4ab4-4f4d-a3bc-8ddbf73876c7
Source identifiers:
453899
Local pid:
pubs:453899

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