Journal article icon

Journal article

A comparison of the pharmacokinetic and pharmacodynamic properties of quinine and quinidine in healthy Thai males.

Abstract:

1. Eight healthy Thai males, aged 19-27 years, received quinine or quinidine dihydrochloride 10 mg kg-1 body weight by intravenous infusion over 1 h. At least 1 week later, the alternative alkaloid was administered. 2. The terminal elimination half-time of quinidine was shorter than that of quinine (median [range]; 5.7 [5.0-10.0] vs 9.9 [8.8-15.1] h, P < 0.01), the volume of distribution at steady state (Vss) for quinidine was larger than that for quinine (3.5 [2.5-5.6] vs 3.1 [1.8-4.1] 1 ...

Expand abstract
Publication status:
Published

Actions


Authors


Karbwang, J More by this author
Looareesuwan, S More by this author
Molunto, P More by this author
Expand authors...
Journal:
British journal of clinical pharmacology
Volume:
35
Issue:
3
Pages:
265-271
Publication date:
1993-03-05
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:7007aa44-c4e9-467c-8285-c5a0e2633581
Source identifiers:
44135
Local pid:
pubs:44135

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP