- Abstract:
-
We examined whether the N-methyl-D-aspartate antagonist MK-801 (dizocilpine) would reverse parkinsonism or potentiate the effects of L-dopa in primates treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In contrast to its effect in rodent models, treatment with MK-801 (0.1 mg/kg) caused bradykinesia and ataxia in parkinsonian primates, but no locomotor stimulation. Coadministration of MK-801 (0.1 mg/kg) with L-dopa (20 mg/kg) induced marked dystonia accompanied by bradykinesia ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/ana.410320118
-
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- Journal:
- Annals of neurology
- Volume:
- 32
- Issue:
- 1
- Pages:
- 103-105
- Publication date:
- 1992-07-05
- DOI:
- EISSN:
-
1531-8249
- ISSN:
-
0364-5134
- URN:
-
uuid:70062681-0c35-4eac-b106-1e44b409de9e
- Source identifiers:
-
18947
- Local pid:
- pubs:18947
- Language:
- English
- Keywords:
- Copyright date:
- 1992
Journal article
Dystonia induced by combined treatment with L-dopa and MK-801 in parkinsonian monkeys.
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