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Dystonia induced by combined treatment with L-dopa and MK-801 in parkinsonian monkeys.

Abstract:

We examined whether the N-methyl-D-aspartate antagonist MK-801 (dizocilpine) would reverse parkinsonism or potentiate the effects of L-dopa in primates treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In contrast to its effect in rodent models, treatment with MK-801 (0.1 mg/kg) caused bradykinesia and ataxia in parkinsonian primates, but no locomotor stimulation. Coadministration of MK-801 (0.1 mg/kg) with L-dopa (20 mg/kg) induced marked dystonia accompanied by bradykinesia ...

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Publication status:
Published

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Publisher copy:
10.1002/ana.410320118

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Annals of neurology
Volume:
32
Issue:
1
Pages:
103-105
Publication date:
1992-07-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:70062681-0c35-4eac-b106-1e44b409de9e
Source identifiers:
18947
Local pid:
pubs:18947

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