- Abstract:
-
Protein secretion through type-three secretion systems (T3SS) is critical for motility and virulence of many bacteria. Proteins are transported through an export gate containing three proteins (FliPQR in flagella, SctRST in virulence systems). A fourth essential T3SS protein (FlhB/SctU) functions to “switch” secretion substrate specificity once the growing hook/needle reach their determined length. Here, we present the cryo-electron microscopy structure of an export gate containing the switch...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1038/s41467-020-15071-9
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- Grant:
- 100298/Z/12/Z
- 100298/Z/12/A
- 201536/Z/16/Z
- 209194/Z/17/Z
- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 11
- Article number:
- 1296
- Publication date:
- 2020-03-10
- Acceptance date:
- 2020-02-15
- DOI:
- EISSN:
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2041-1723
- Pubs id:
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1087870
- Local pid:
- pubs:1087870
- Language:
- English
- Keywords:
- Copyright holder:
- Kuhlen et al.
- Rights statement:
- Copyright © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- License:
- CC Attribution (CC BY)
Journal article
The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion
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