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The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion

Abstract:

Protein secretion through type-three secretion systems (T3SS) is critical for motility and virulence of many bacteria. Proteins are transported through an export gate containing three proteins (FliPQR in flagella, SctRST in virulence systems). A fourth essential T3SS protein (FlhB/SctU) functions to “switch” secretion substrate specificity once the growing hook/needle reach their determined length. Here, we present the cryo-electron microscopy structure of an export gate containing the switch...

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Publication status:
Published
Peer review status:
Peer reviewed

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John Fell Fund More from this funder
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Grant:
100298/Z/12/Z
100298/Z/12/A
201536/Z/16/Z
209194/Z/17/Z
Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Article number:
1296
Publication date:
2020-03-10
Acceptance date:
2020-02-15
DOI:
EISSN:
2041-1723
Pubs id:
1087870
Local pid:
pubs:1087870
Language:
English
Keywords:

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