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Cell- and protein-directed glycosylation of native cleaved HIV-1 envelope

Abstract:

The gp120/gp41 HIV-1 envelope glycoprotein (Env) is highly glycosylated, with up to 50% of its mass consisting of N-linked glycans. This dense carbohydrate coat has emerged as a promising vaccine target, with its glycans acting as epitopes for a number of potent and broadly neutralizing antibodies (bnAbs). Characterizing the glycan structures present on native HIV-1 Env is thus a critical goal for the design of Env immunogens. In this study, we used a complementary, multistep approach involvi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/JVI.01190-15

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Department:
Oxford, MSD, Biochemistry
Role:
Author

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Editor
Department of Health More from this funder
NIAID NIH HHS More from this funder
Medical Research Council More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
89
Issue:
17
Pages:
8932-8944
Publication date:
2015-06-17
Acceptance date:
2015-06-08
DOI:
ISSN:
0022-538X and 1098-5514
Pubs id:
pubs:607248
URN:
uri:6fdc7d93-b6fa-4b12-b895-b7da6a33fc8d
UUID:
uuid:6fdc7d93-b6fa-4b12-b895-b7da6a33fc8d
Local pid:
pubs:607248
Paper number:
17

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