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Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion.

Abstract:

Collagen fibers affect metastasis in two opposing ways, by supporting invasive cells but also by generating a barrier to invasion. We hypothesized that these functions might be performed by different isoforms of type I collagen. Carcinomas are reported to contain alpha1(I)(3) homotrimers, a type I collagen isoform normally not present in healthy tissues, but the role of the homotrimers in cancer pathophysiology is unclear. In this study, we found that these homotrimers were resistant to all c...

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Publication status:
Published

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Journal:
Cancer research
Volume:
70
Issue:
11
Pages:
4366-4374
Publication date:
2010-06-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Source identifiers:
226503
Language:
English
Keywords:
Pubs id:
pubs:226503
UUID:
uuid:6fd20464-01e4-4c1d-892c-2f1410312109
Local pid:
pubs:226503
Deposit date:
2012-12-19

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