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Journal article

Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine.

Abstract:

BACKGROUND: The target enzyme of pyrimethamine is dihydrofolate reductase (DHFR), but little is known about allelic variants of dhfr in Plasmodium vivax populations. Still less is known about associations between specific alleles and the failure of sulfadoxine/pyrimethamine (S/P) to clear the erythrocytic stages of P. vivax in vivo. METHODS: We studied P. vivax dhfr mutations in 24 patients who received S/P therapy in Papua or Central Java, Indonesia, and we measured the resistance of the al...

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Publication status:
Published

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Publisher copy:
10.1086/381397

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Journal:
The Journal of infectious diseases
Volume:
189
Issue:
4
Pages:
744-750
Publication date:
2004-02-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:6fca7f7d-8d04-4d4e-a5fc-c958747d3af6
Source identifiers:
81667
Local pid:
pubs:81667

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