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Journal article

Photoinduced, family-specific, site-selective cleavage of TIM-barrel proteins.

Abstract:

Nonenzymatic, chemical methods for the controlled cleavage of proteins at predictable sites in a site-specific manner are rare and of strong potential utility in clean, post-translational manipulation of protein structure for use in, for example, proteomics, sequencing, and tagged-protein production. Unprecedented photochemical, site-selective cleavage of a His-Trp (HW) motif in the GH1 family TIM-barrel proteins is observed upon exposure to 240-308 nm light to cleanly release N-terminal prim...

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Publication status:
Published

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Publisher copy:
10.1021/ja9026105

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Plant Sciences
Role:
Author
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Journal:
Journal of the American Chemical Society
Volume:
131
Issue:
35
Pages:
12518-12519
Publication date:
2009-09-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:6fb6cb68-1d71-4e2f-9dd3-2a4734fa98da
Source identifiers:
34866
Local pid:
pubs:34866

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