- Abstract:
-
Nonenzymatic, chemical methods for the controlled cleavage of proteins at predictable sites in a site-specific manner are rare and of strong potential utility in clean, post-translational manipulation of protein structure for use in, for example, proteomics, sequencing, and tagged-protein production. Unprecedented photochemical, site-selective cleavage of a His-Trp (HW) motif in the GH1 family TIM-barrel proteins is observed upon exposure to 240-308 nm light to cleanly release N-terminal prim...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/ja9026105
-
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- Journal:
- Journal of the American Chemical Society
- Volume:
- 131
- Issue:
- 35
- Pages:
- 12518-12519
- Publication date:
- 2009-09-05
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- URN:
-
uuid:6fb6cb68-1d71-4e2f-9dd3-2a4734fa98da
- Source identifiers:
-
34866
- Local pid:
- pubs:34866
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Photoinduced, family-specific, site-selective cleavage of TIM-barrel proteins.
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