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Journal article

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination

Abstract:
PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules. ©The Authors.

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Publisher copy:
10.1042/BST0351501

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Biochemical Society Transactions
Volume:
35
Issue:
6
Pages:
1501-1503
Publication date:
2007-12-01
DOI:
ISSN:
0300-5127
Source identifiers:
226213
Language:
English
Keywords:
Pubs id:
pubs:226213
UUID:
uuid:6fb1d51f-3284-4fe7-97e3-60d86c85caaa
Local pid:
pubs:226213
Deposit date:
2012-12-19

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