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Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination

Abstract:
PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules. ©The Authors.

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Publisher copy:
10.1042/BST0351501

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Biochemical Society Transactions
Volume:
35
Issue:
6
Pages:
1501-1503
Publication date:
2007-12-05
DOI:
ISSN:
0300-5127
URN:
uuid:6fb1d51f-3284-4fe7-97e3-60d86c85caaa
Source identifiers:
226213
Local pid:
pubs:226213

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