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Journal article

ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma

Abstract:

Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size =  -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-con...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1004089

Authors


Nongpiur, ME More by this author
Cornes, BK More by this author
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Howard Hughes Medical Institute More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
10
Issue:
3
Pages:
e1004089
Publication date:
2014-03-06
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:457769
URN:
uri:6facdebc-4c5e-4a75-ad14-fdb2f0f66aa5
UUID:
uuid:6facdebc-4c5e-4a75-ad14-fdb2f0f66aa5
Local pid:
pubs:457769

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