Journal article icon

Journal article

Canonical Notch signaling is dispensible for adult steady-state and stress myelo-erythropoiesis

Abstract:

While an essential role for canonical Notch signaling in generation of hematopoietic stem cells in the embryo and in thymic T cell development is well established, its role in adult bone marrow (BM) myelopoiesis remains unclear. Some studies, analyzing myeloid progenitors in adult mice with inhibited Notch signaling, implicated distinct roles of canonical Notch signaling in regulation of progenitors for the megakaryocyte, erythroid and granulocyte-macrophage cell lineages. However, these stud...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1182/blood-2017-06-788505

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0002-7641-175X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
ORCID:
0000-0002-2340-2526
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; Weatherall Insti. of Molecular Medicine
Role:
Author
Expand authors...
EUFPEuroSyStem Integrated project More from this funder
Swedish Research Council More from this funder
Knut and Alice Wallenberg Foundation More from this funder
Expand funders...
Publisher:
American Society of Hematology Publisher's website
Journal:
Blood Journal website
Volume:
131
Issue:
15
Pages:
1712-1719
Publication date:
2018-01-16
Acceptance date:
2018-01-10
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Pubs id:
pubs:821321
URN:
uri:6fa5cf63-6f03-40b0-b629-11803f1ee8a4
UUID:
uuid:6fa5cf63-6f03-40b0-b629-11803f1ee8a4
Local pid:
pubs:821321
Language:
English

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP