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Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart

Abstract:

Repolarization alternans is related to the initiation of life threatening cardiac arrhythmias. Experimental and computational studies suggest that the abolishment of alternans using dynamic pacing protocols may prevent abnormal heart rhythms. In a recent animal study, refractory period pacing (RPP) on every other beat has shown promising results in alternans reduction. However, the cellular mechanisms underlying this therapy and its efficiency in human patients remain unclear. In this study, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1109/EMBC.2016.7590664

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Publisher:
Institute of Electrical and Electronics Engineers Publisher's website
Journal:
IEEE 38th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC), Orlando, FL, USA, 2016 Journal website
Host title:
IEEE 38th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC), Orlando, FL, USA, 2016
Publication date:
2016-08-20
Acceptance date:
2016-08-16
Event location:
United States
DOI:
EISSN:
1558-4615
ISSN:
1557-170X
Source identifiers:
672424
ISBN:
9781457702204
Pubs id:
pubs:672424
UUID:
uuid:6fa13551-5798-4a74-98e2-4f9639b9930a
Local pid:
pubs:672424
Deposit date:
2017-04-24

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