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Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart

Abstract:

Repolarization alternans is related to the initiation of life threatening cardiac arrhythmias. Experimental and computational studies suggest that the abolishment of alternans using dynamic pacing protocols may prevent abnormal heart rhythms. In a recent animal study, refractory period pacing (RPP) on every other beat has shown promising results in alternans reduction. However, the cellular mechanisms underlying this therapy and its efficiency in human patients remain unclear. In this study, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1109/EMBC.2016.7590664

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Department:
Oxford, MPLS, Computer Science
Role:
Author
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Department:
Oxford, MPLS, Computer Science
Role:
Author
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Publisher:
Institute of Electrical and Electronics Engineers Publisher's website
Publication date:
2016-08-20
Acceptance date:
2016-08-16
DOI:
EISSN:
1558-4615
ISSN:
1557-170X
Pubs id:
pubs:672424
URN:
uri:6fa13551-5798-4a74-98e2-4f9639b9930a
UUID:
uuid:6fa13551-5798-4a74-98e2-4f9639b9930a
Local pid:
pubs:672424
ISBN:
9781457702204

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