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A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects.

Abstract:

BACKGROUND: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations. OBJECTIVE: We tested whether raising plasma free fatty acids by using a high-fat, low-carbohydrate diet results in alterations in heart and brain in healthy subjects. DESIGN: Men (n = 16) aged 22 ± 1 y (mean ± SE) were randomly assigned to 5 d of a high-fat, low-carbohydrate diet containing 75 ± 1% of calorie in...

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Publication status:
Published

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Publisher copy:
10.3945/ajcn.110.002758

Authors


Holloway, CJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Emmanuel, Y More by this author
Codreanu, I More by this author
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Journal:
The American journal of clinical nutrition
Volume:
93
Issue:
4
Pages:
748-755
Publication date:
2011-04-05
DOI:
EISSN:
1938-3207
ISSN:
0002-9165
URN:
uuid:6f95df1c-1706-44e7-94be-10eb2409d064
Source identifiers:
113368
Local pid:
pubs:113368

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