- Abstract:
-
In experimental transplantation, blockade of CD40-CD40 ligand (CD40L) interactions has proved effective at permitting long-term graft survival and has recently been approved for clinical evaluation. We show that CD4+ T cell-mediated rejection is prevented by anti-CD40L mAb therapy but that CD8+ T cells remain fully functional. Furthermore, blocking CD40L interactions has no effect on CD8+ T cell activation, proliferation, differentiation, homing to the target allograft, or cytokine production...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.165.2.1111
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 165
- Issue:
- 2
- Pages:
- 1111-1118
- Publication date:
- 2000-07-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:6f919ebb-ec70-42a4-85ed-2f77ad032522
- Source identifiers:
-
135918
- Local pid:
- pubs:135918
- Language:
- English
- Keywords:
- Copyright date:
- 2000
Journal article
CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection.
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