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Journal article

CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection.

Abstract:

In experimental transplantation, blockade of CD40-CD40 ligand (CD40L) interactions has proved effective at permitting long-term graft survival and has recently been approved for clinical evaluation. We show that CD4+ T cell-mediated rejection is prevented by anti-CD40L mAb therapy but that CD8+ T cells remain fully functional. Furthermore, blocking CD40L interactions has no effect on CD8+ T cell activation, proliferation, differentiation, homing to the target allograft, or cytokine production...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.165.2.1111

Authors


Van Maurik, A More by this author
Spriewald, BM More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
165
Issue:
2
Pages:
1111-1118
Publication date:
2000-07-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:6f919ebb-ec70-42a4-85ed-2f77ad032522
Source identifiers:
135918
Local pid:
pubs:135918

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