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Antibody-mediated suppression of the immune response in vitro. II. A new approach to the phenomenon of immunological tolerance.

Abstract:

Immunological tolerance to H antigens of Salmonella adelaide may be induced in vitro by the exposure of mouse spleen cells for 6 hr to an immunogenic dose of polymerized flagellin in the presence of low concentrations of specific antibody. Such antibody-mediated tolerance requires an optimal antigen: antibody ratio for its induction. A shift in this ratio in favor of the antibody concentration results in failure of tolerance induction and leads to immune suppression commonly known as antibody...

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Publisher copy:
10.1084/jem.132.1.31

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
132
Issue:
1
Pages:
31-43
Publication date:
1970-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:6f8ee675-9444-4134-a7df-38e5feca5c15
Source identifiers:
482240
Local pid:
pubs:482240

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