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A two-compartment mechanochemical model of the roles of transforming growth factor β and tissue tension in dermal wound healing.

Abstract:

The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion. Recent experimental results have shown that transforming growth factor -β (TGFβ) and tissue mechanics play roles in regulating cell proliferation, differentiation and the production of extracellular materials. We have developed a 1D mathematical model that considers the interaction between the cellular, ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jtbi.2010.12.011

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of theoretical biology
Volume:
272
Issue:
1
Pages:
145-159
Publication date:
2011-03-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:6f8a008b-d468-4217-b065-f69108088082
Source identifiers:
149576
Local pid:
pubs:149576

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