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Synthesis of fully substituted polyhydroxylated pyrrolizidines via Cope-House cyclization.

Abstract:: Total synthesis of the proposed structure of (-)-hyacinthacine C(5) and its epimers at C6 and C7 is described. A key step of the synthesis was the construction of the bicyclic pyrrolizidine system by means of a nucleophilic addition of a dithiane to a cyclic nitrone followed by a Cope-House cyclization.

Publication status:: Published

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APA Style

Zhang, W., Sato, K., Kato, A., Jia, Y., Hu, X., Wilson, F., van Well, R., Horne, G., Fleet, G., Nash, R., & Yu, C. (2011). Synthesis of fully substituted polyhydroxylated pyrrolizidines via Cope-House cyclization. Organic Letters, 13(16), 4414–4417.

MLA Style

Zhang, W., et al. “Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope-House Cyclization.” Organic Letters, vol. 13, no. 16, 2011, pp. 4414–17.

Chicago Style

Zhang, W, K Sato, A Kato, Y Jia, X Hu, F Wilson, R van Well, et al. 2011. “Synthesis of Fully Substituted Polyhydroxylated Pyrrolizidines via Cope-House Cyclization.” Organic Letters 13 (16): 4414–17.
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Publisher copy:: 10.1021/ol201749c

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+ Zhang, W More by this author

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+ Sato, K More by this author

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+ Kato, A More by this author

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+ Jia, Y More by this author

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+ Hu, X More by this author

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Bibliographic Details

Journal:: Organic letters
Volume:: 13
Issue:: 16
Pages:: 4414-4417
Publication date:: 2011-08-01
DOI:: 10.1021/ol201749c
EISSN:: 1523-7052
ISSN:: 1523-7060

Item Description

Language:: English
Keywords:: Pyrrolizidine Alkaloids

Cyclization

Hydroxylation

Molecular Structure
Pubs id:: pubs:175435
UUID:: uuid:6f75bcae-f26e-4a44-be64-436aba9f21a7
Local pid:: pubs:175435
Source identifiers:: 175435
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2011

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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