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A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits

Abstract:

Multiple rare variants either within or across genes have been hypothesised to collectively influence complex human traits. The increasing availability of high throughput sequencing technologies offers the opportunity to study the effect of rare variants on these traits. However, appropriate and computationally efficient analytical methods are required to account for collections of rare variants that display a combination of protective, deleterious and null effects on the trait. We have devel...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1003694

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS Genetics More from this journal
Volume:
9
Issue:
8
Pages:
ARTN e1003694
Publication date:
2013-08-15
Acceptance date:
2013-06-19
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Language:
English
Keywords:
UUID:
uuid:6f631d49-efca-4977-a788-92bb237d40b7
Local pid:
pubs:420875
Source identifiers:
420875
Deposit date:
2013-11-16

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