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Quenching protein dynamics interferes with HIV capsid maturation.

Abstract:

Maturation of HIV-1 particles encompasses a complex morphological transformation of Gag via an orchestrated series of proteolytic cleavage events. A longstanding question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA-SP1), which represents an intermediate during maturation of the HIV-1 virus. By integrating NMR, cryo-EM, and molecular dynamics simulations, we show that in CA-SP1 tubes assembled in vitro, which represent the features of an intermediate assembly ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-1171-6816
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Name:
National Institutes of Health
Grant:
P41 GM104601
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Name:
National Science Foundation
Publisher:
Nature Publishing Group
Journal:
Nature Communications More from this journal
Volume:
8
Issue:
1
Pages:
1779
Publication date:
2017-11-01
Acceptance date:
2017-10-19
DOI:
EISSN:
2041-1723
Pmid:
29176596
Language:
English
Keywords:
Pubs id:
pubs:803748
UUID:
uuid:6f62a7ef-955b-47f0-8503-b5ab8490e407
Local pid:
pubs:803748
Source identifiers:
803748
Deposit date:
2018-01-24

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