Journal article
Quenching protein dynamics interferes with HIV capsid maturation.
- Abstract:
-
Maturation of HIV-1 particles encompasses a complex morphological transformation of Gag via an orchestrated series of proteolytic cleavage events. A longstanding question concerns the structure of the C-terminal region of CA and the peptide SP1 (CA-SP1), which represents an intermediate during maturation of the HIV-1 virus. By integrating NMR, cryo-EM, and molecular dynamics simulations, we show that in CA-SP1 tubes assembled in vitro, which represent the features of an intermediate assembly ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
National Science Foundation
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State of Illinois
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Issue:
- 1
- Pages:
- 1779
- Publication date:
- 2017-11-01
- Acceptance date:
- 2017-10-19
- DOI:
- EISSN:
-
2041-1723
- Pmid:
-
29176596
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:803748
- UUID:
-
uuid:6f62a7ef-955b-47f0-8503-b5ab8490e407
- Local pid:
- pubs:803748
- Source identifiers:
-
803748
- Deposit date:
- 2018-01-24
Terms of use
- Copyright holder:
- Zhang et al
- Copyright date:
- 2017
- Notes:
- © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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