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Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure.

Abstract:

Accumulating evidence implicates nicotinic acid adenine dinucleotide phosphate (NAADP) in the control of Ca(2+)-dependent functions. Little, however, is known concerning its role in the vascular endothelium, a major regulator of blood pressure. Here, we show that NAADP acetoxymethyl ester (NAADP-AM), a cell-permeant NAADP analog, increases cytosolic Ca(2+) concentration in aortic endothelial cells. We demonstrate that these signals and those evoked by acetylcholine are blocked by disrupting a...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.c110.169763

Authors


Brailoiu, GC More by this author
Parkesh, R More by this author
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Journal:
The Journal of biological chemistry
Volume:
285
Issue:
48
Pages:
37133-37137
Publication date:
2010-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:6f5eb31c-b882-4f66-8c51-c954c72cacd7
Source identifiers:
106532
Local pid:
pubs:106532

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