- Abstract:
-
Accumulating evidence implicates nicotinic acid adenine dinucleotide phosphate (NAADP) in the control of Ca(2+)-dependent functions. Little, however, is known concerning its role in the vascular endothelium, a major regulator of blood pressure. Here, we show that NAADP acetoxymethyl ester (NAADP-AM), a cell-permeant NAADP analog, increases cytosolic Ca(2+) concentration in aortic endothelial cells. We demonstrate that these signals and those evoked by acetylcholine are blocked by disrupting a...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.c110.169763
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 285
- Issue:
- 48
- Pages:
- 37133-37137
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:6f5eb31c-b882-4f66-8c51-c954c72cacd7
- Source identifiers:
-
106532
- Local pid:
- pubs:106532
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure.
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