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Vital functions of the malarial ookinete protein, CTRP, reside in the A domains.

Abstract:

The transformation of malaria ookinetes into oocysts occurs in the mosquito midgut and is a major bottleneck for parasite transmission. The secreted ookinete surface protein, circumsporozoite- and thrombospondin-related adhesive protein (TRAP)-related protein (CTRP), is essential for this transition and hence constitutes a potential target for malaria transmission blockade. CTRP is a modular multidomain protein containing six tandem von Willebrand factor A-like (A) domains and seven tandem th...

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Publication status:
Published

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Authors


Ramakrishnan, C More by this author
Dessens, JT More by this author
Talman, AM More by this author
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Journal:
International journal for parasitology
Volume:
41
Issue:
10
Pages:
1029-1039
Publication date:
2011-08-05
DOI:
EISSN:
1879-0135
ISSN:
0020-7519
URN:
uuid:6f5d2079-cd84-4c25-ac72-0d2fb2d052f1
Source identifiers:
268045
Local pid:
pubs:268045

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