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Eight-plex iTRAQ analysis of variant metastatic human prostate cancer cells identifies candidate biomarkers of progression: An exploratory study.

Abstract:

BACKGROUND: Due to the heterogeneity in the biological behavior of prostate cancer, biomarkers that can reliably distinguish indolent from aggressive disease are urgently needed to inform treatment choices. METHODS: We employed 8-plex isobaric Tags for Relative and Absolute Quantitation (iTRAQ), to profile the proteomes of two distinct panels of isogenic prostate cancer cells with varying growth and metastatic potentials, in order to identify novel biomarkers associated with progression. The ...

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Publication status:
Published

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Publisher copy:
10.1002/pros.21167

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences, Biomedical Research Centre
Role:
Author
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Journal:
The Prostate
Volume:
70
Issue:
12
Pages:
1313-1332
Publication date:
2010-09-05
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
URN:
uuid:6f5c8d33-75a6-4649-8554-64abec3469e3
Source identifiers:
120612
Local pid:
pubs:120612

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