Total synthesis of spirastrellolide A methyl ester--part 2: Subunit union and completion of the synthesis.
(Figure Presented) Succumbing to synthesis: The stereocontrolled total synthesis of spirastrellolide A methyl ester is reported. The union of two key C1-C16 and C17-C40 subunits is followed by macrolactonization and late-stage side chain attachment by a cross-metathesis reaction anda π-allyl Stille coupling reaction with a C43-C47 stannane, thus confirming the 46R configuration. The full configuration and conformation of the 38-membered macrolide is revealed by single-crystal X-ray analysis o...Expand abstract
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