- Abstract:
-
(Figure Presented) Succumbing to synthesis: The stereocontrolled total synthesis of spirastrellolide A methyl ester is reported. The union of two key C1-C16 and C17-C40 subunits is followed by macrolactonization and late-stage side chain attachment by a cross-metathesis reaction anda π-allyl Stille coupling reaction with a C43-C47 stannane, thus confirming the 46R configuration. The full configuration and conformation of the 38-membered macrolide is revealed by single-crystal X-ray analysis o...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/anie.200705566
-
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- Journal:
- Angewandte Chemie (International ed. in English)
- Volume:
- 47
- Issue:
- 16
- Pages:
- 3021-3025
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
- URN:
-
uuid:6f5b6d18-b95e-452d-adf4-0b85e9bab679
- Source identifiers:
-
117841
- Local pid:
- pubs:117841
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Total synthesis of spirastrellolide A methyl ester--part 2: Subunit union and completion of the synthesis.
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