The mosquito transmission of malaria: the effects of atovaquone-proguanil (Malarone) and chloroquine.

Journal article

Despite its recognized importance, the prevention of patients with malaria from continuing to infect mosquitoes after treatment is not always achieved in practice. An inevitable consequence of the prolonged life-span and relative metabolic stasis of the mature gametocytes of Plasmodium falciparum is that they are not cleared by most antimalarials, and few antimalarials block infection in the mosquito vector. Previous research on the constituents of Malarone, a new 'combined antimalarial', sug...

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Authors: Enosse, S; Butcher, G; Margos, G; Mendoza, J; Sinden, R

• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
• Volume: 94
• Issue: 1
• Pages: 77-82
• Publication date: 2000-01-01
• DOI: 10.1016/s0035-9203(00)90447-4
• EISSN: 1878-3503
• ISSN: 0035-9203
• Language: English
• Keywords: Humans; Statistics, Nonparametric; Animals; Naphthoquinones; Culicidae; Insect Vectors; Drug Combinations; Plasmodium falciparum; Plasmodium berghei; Antimalarials; Mice; Malaria; Chloroquine; Proguanil; Atovaquone