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Scavenger receptor A: a new route for adenovirus 5.

Abstract:

Adenoviruses are common pathogens associated with respiratory diseases, gastrointestinal illnesses and/or conjunctivitis. Currently, this virus is used as a vector in gene therapy trials. The promise of viral gene therapy applications is substantially reduced because the virus is cleared by liver macrophages upon systemic administration. The mechanism underlying adenoviral tropism to and degradation in macrophages is poorly understood. We identified a new adenoviral receptor, the scavenger re...

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Publication status:
Published

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Publisher copy:
10.1021/mp8000974

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Journal:
Molecular pharmaceutics
Volume:
6
Issue:
2
Pages:
366-374
Publication date:
2009-01-01
DOI:
EISSN:
1543-8392
ISSN:
1543-8384
URN:
uuid:6f53ce65-3606-4dcf-82bf-2925dc788d0b
Source identifiers:
6018
Local pid:
pubs:6018

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