Journal article
Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.
- Abstract:
-
Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We here describe a novel application of cytotoxic saporin-conjugated tetramers to kill antigen-specific T-cells without significant off-target effects. The relative efficacy of distinct antiviral CD8+ T-...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institute for Health Research
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Clarendon Fund
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS one Journal website
- Volume:
- 12
- Issue:
- 10
- Pages:
- e0184496
- Publication date:
- 2017-10-01
- Acceptance date:
- 2017-08-24
- DOI:
- EISSN:
-
1932-6203
- Pmid:
-
29020090
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:737238
- UUID:
-
uuid:6f4eda91-0a80-48b9-af0c-7a6738903dae
- Local pid:
- pubs:737238
- Source identifiers:
-
737238
- Deposit date:
- 2017-10-26
Terms of use
- Copyright holder:
- Leitman et al
- Copyright date:
- 2017
- Notes:
- © 2017 Leitman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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