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Mammalian EGF receptor activation by the rhomboid protease RHBDL2.

Abstract:

The epidermal growth factor receptor (EGFR) has several functions in mammalian development and disease, particularly cancer. Most EGF ligands are synthesized as membrane-tethered precursors, and their proteolytic release activates signalling. In Drosophila, rhomboid intramembrane proteases catalyse the release of EGF-family ligands; however, in mammals this seems to be primarily achieved by ADAM-family metalloproteases. We report here that EGF is an efficient substrate of the mammalian rhombo...

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Publication status:
Published

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Publisher copy:
10.1038/embor.2011.50

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Journal:
EMBO reports More from this journal
Volume:
12
Issue:
5
Pages:
421-427
Publication date:
2011-05-01
DOI:
EISSN:
1469-3178
ISSN:
1469-221X

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