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Binding of nuclear factor kappa B to non-canonical consensus sites reveals its multimodal role during the early inflammatory response

Abstract:

Mammalian cells have developed intricate mechanisms to interpret, integrate, and respond to extra-cellular stimuli. For example, tumor necrosis factor (TNF) rapidly activates proinflammatory genes, but our understanding of how this occurs against the ongoing transcriptional program of the cell is far from complete. We monitor the early phase of this cascade at high spatio-temporal resolution in TNFα-stimulated human endothelial cells. The main driver of the response, NF-κB, hijacks the regula...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1101/gr.210005.116

Authors


Kolovos, P More by this author
Georgomanolis, T More by this author
Koeferle, A More by this author
Larkin, JD More by this author
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Funding agency for:
Cook, P
Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genome Research Journal website
Volume:
26
Issue:
11
Pages:
1478-1489
Publication date:
2016-09-15
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Pubs id:
pubs:645193
URN:
uri:6f47ab7d-d5ae-4e77-a2cd-824d5357b676
UUID:
uuid:6f47ab7d-d5ae-4e77-a2cd-824d5357b676
Local pid:
pubs:645193

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