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Journal article

Binding of nuclear factor kappa B to non-canonical consensus sites reveals its multimodal role during the early inflammatory response

Abstract:

Mammalian cells have developed intricate mechanisms to interpret, integrate, and respond to extra-cellular stimuli. For example, tumor necrosis factor (TNF) rapidly activates proinflammatory genes, but our understanding of how this occurs against the ongoing transcriptional program of the cell is far from complete. We monitor the early phase of this cascade at high spatio-temporal resolution in TNFα-stimulated human endothelial cells. The main driver of the response, NF-κB, hijacks the regula...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/gr.210005.116

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Funding agency for:
Cook, P
Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genome Research Journal website
Volume:
26
Issue:
11
Pages:
1478-1489
Publication date:
2016-09-15
Acceptance date:
2016-09-14
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Pmid:
27633323
Source identifiers:
645193
Language:
English
Keywords:
Pubs id:
pubs:645193
UUID:
uuid:6f47ab7d-d5ae-4e77-a2cd-824d5357b676
Local pid:
pubs:645193
Deposit date:
2016-09-30

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