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Aging mechanisms in arthritic disease.

Abstract:

Arthritic disease is one of the most common age-related pathologies worldwide. The erosion of cartilaginous tissues from articular surfaces within the joint and the failure to efficiently repair and regenerate this region with age lead to debilitating joint destruction, severe pain, and a crippling loss of function. In addition to the accumulative damage brought about by years of mechanical forces acting upon this region of tissue, there are also defects in underlying biological mechanisms wh...

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Publication status:
Published

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Authors


Sacitharan, PK More by this author
Snelling, SJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Discovery medicine
Volume:
14
Issue:
78
Pages:
345-352
Publication date:
2012-11-05
EISSN:
1944-7930
ISSN:
1539-6509
URN:
uuid:6f462c3e-fd0a-4251-afb8-0ab6ff9a3a18
Source identifiers:
365532
Local pid:
pubs:365532

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