Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives.

Conference item

Abstract:: Reliable and reproducible methods for the measurements of artemisinin and its derivatives in body fluids have proved difficult to develop. The available evidence suggests that all compounds are hydrolysed to a biologically active metabolite, dihydroartemisinin, which is eliminated rapidly. The role of other (hydroxylated) metabolites in humans requires further study. The hydrolysis of artesunate is so rapid that it may be considered a pro-drug for dihydroartemisinin. All the artemisinin compo...
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Institution:

University of Oxford

Division:

MSD

Department:

NDM

Role:

Author

Host title:: Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:: 88 Suppl 1
Issue:: SUPPL. 1
Pages:: S41-S43
Publication date:: 1994-06-01
Event location:: ENGLAND
DOI:: 10.1016/0035-9203(94)90471-5
EISSN:: 1878-3503
ISSN:: 0035-9203

Keywords:: Sesquiterpenes

Humans

Parasites

Animals

Antiprotozoal Agents

Antimalarials

Artemisinins
Pubs id:: pubs:44608
UUID:: uuid:6f38ebca-f8f1-433e-a91c-34e425b15f15
Local pid:: pubs:44608
Source identifiers:: 44608
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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