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Mechanosensing in T lymphocyte activation.

Abstract:

Mechanical forces play an increasingly recognized role in modulating cell function. This report demonstrates mechanosensing by T cells, using polyacrylamide gels presenting ligands to CD3 and CD28. Naive CD4 T cells exhibited stronger activation, as measured by attachment and secretion of IL-2, with increasing substrate elastic modulus over the range of 10-200 kPa. By presenting these ligands on different surfaces, this report further demonstrates that mechanosensing is more strongly associat...

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Publisher copy:
10.1016/j.bpj.2011.12.011

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Biophysical journal More from this journal
Volume:
102
Issue:
2
Publication date:
2012-01-18
DOI:
EISSN:
1542-0086
Language:
English
Pubs id:
pubs:426324
UUID:
uuid:6f38061a-b4f0-40df-a422-4b48608b02bd
Local pid:
pubs:426324
Source identifiers:
426324
Deposit date:
2014-07-10

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